Run projects on IIS
Depending on your operation system and IIS version, use one of the following procedures to host and run your Sitefinity CMS project on Microsoft Internet Information Services.
First, you need to turn on the IIS and configure your server, then, you create or the project and run it on the IIS. To configure the server, you can use one of the provided PowerShell scripts or perform the manual procedure.
If you are using Multisite, you can run all of your sites under one application pool with different bindings.